Actual patients. Results may vary.
Photos taken at full smile before and after treatment with BOTOX®
Cosmetic (onabotulinumtoxinA) at day 7. In two clinical studies, 26.1% and 20.3% of people had
≥ 2-grade improvement at day 30.1 In one of these studies, 67.9%
of people had mild or no crow’s feet at day 30 after treatment.2
Photos taken at maximum frown before and after treatment with
BOTOX® Cosmetic (onabotulinumtoxinA) at day 7. In clinical
studies, physicians assessed 80% of people had significant improvement at day 30.1
Photos taken at maximum frown and/or full smile before and after treatment with BOTOX® Cosmetic (onabotulinumtoxinA) at day 7. In two clinical
studies for moderate to severe crow’s feet, 26.1% and 20.3% of people had ≥ 2-grade improvement at day 30.1 In one of these studies, 67.9% of
people had mild or no crow’s feet at day 30 after treatment.2 In clinical studies for
moderate to severe frown lines, physicians assessed 80% of people had significant improvement at day
Side effects associated with the injection include localized pain, infection, inflammation, tenderness,
swelling, redness, and/or bleeding/bruising.1
BOTOX® Cosmetic is a prescription medicine that is injected into muscles and used to improve the
look of moderate to severe frown lines between the eyebrows (glabellar lines) in adults for a short period of
BOTOX® Cosmetic is a prescription medicine that is injected into the area around the side of the
eyes to improve the look of moderate to severe crow’s feet lines in adults for a short period of time
IMPORTANT SAFETY INFORMATION
BOTOX® Cosmetic may cause serious side effects that can be life threatening. Call your doctor
or get medical help right away if you have any of these problems any time (hours to weeks) after injection
of BOTOX® Cosmetic:
- Problems swallowing, speaking, or breathing, due to weakening of associated muscles, can be
severe and result in loss of life. You are at the highest risk if these problems are pre-existing before
injection. Swallowing problems may last for several months
- Spread of toxin effects. The effect of botulinum toxin may affect areas away from the injection
site and cause serious symptoms including: loss of strength and all-over muscle weakness, double vision,
blurred vision and drooping eyelids, hoarseness or change or loss of voice (dysphonia), trouble saying
words clearly (dysarthria), loss of bladder control, trouble breathing, trouble swallowing. If this
happens, do not drive a car, operate machinery, or do other dangerous activities
The dose of BOTOX® Cosmetic is not the same as, or comparable to, any other botulinum toxin
There has not been a confirmed serious case of spread of toxin effect when BOTOX® Cosmetic has
been used at the recommended dose to treat frown lines, crow’s feet lines or both at the same time.
Serious and/or immediate allergic reactions have been reported. They include: itching,
rash, red itchy welts, wheezing, asthma symptoms, or dizziness or feeling faint. Tell your doctor or get medical
help right away if you are wheezing or have asthma symptoms, or if you become dizzy or faint.
Do not take BOTOX® Cosmetic if you: are allergic to any of the
ingredients in BOTOX® Cosmetic (see Medication Guide for ingredients); had an allergic reaction
to any other botulinum toxin product such as Myobloc® (rimabotulinumtoxinB),
Dysport® (abobotulinumtoxinA), or Xeomin® (incobotulinumtoxinA);
have a skin infection at the planned injection site.
Tell your doctor about all your muscle or nerve conditions, such as amyotrophic lateral sclerosis (ALS
or Lou Gehrig’s disease), myasthenia gravis, or Lambert-Eaton syndrome, as you may be at increased risk of
serious side effects including severe dysphagia (difficulty swallowing) and respiratory compromise (difficulty
breathing) from typical doses of BOTOX® Cosmetic.
Tell your doctor about all your medical conditions, including: plans to have surgery;
had surgery on your face; weakness of forehead muscles, such as trouble raising your eyebrows; drooping eyelids;
any other abnormal facial change; are pregnant or plan to become pregnant (it is not known if
BOTOX® Cosmetic can harm your unborn baby); are breast-feeding or plan to breast-feed (it is not
known if BOTOX® Cosmetic passes into breast milk).
Tell your doctor about all the medicines you take, including prescription and
nonprescription medicines, vitamins, and herbal products. Using BOTOX® Cosmetic with certain
other medicines may cause serious side effects. Do not start any new medicines until you have told your
doctor that you have received BOTOX® Cosmetic in the past.
Especially tell your doctor if you: have received any other botulinum toxin product in the last 4 months; have
received injections of botulinum toxin, such as Myobloc®, Dysport®,
or Xeomin® in the past (be sure your doctor knows exactly which product you received);
have recently received an antibiotic by injection; take muscle relaxants; take an allergy or cold medicine; take
a sleep medicine; take anti-platelets (aspirin-like products) or anti-coagulants (blood thinners).
Other side effects of BOTOX® Cosmetic include: dry mouth, discomfort or pain at the
injection site, tiredness, headache, neck pain, and eye problems: double vision, blurred vision, decreased
eyesight, drooping eyelids, swelling of your eyelids, and dry eyes.
For more information refer to the Medication Guide or talk with your doctor.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch
or call 1-800-FDA-1088.
1. BOTOX® Cosmetic Prescribing Information, September 2013.
2. Data on file, Allergan, Inc., December 30, 2013.
Dysport is a registered trademark of Ipsen Biopharm Limited.
Myobloc is a registered trademark of Solstice Neurosciences, Inc.
Xeomin is a registered trademark of Merz Pharma GmbH & Co. KGaA.
www.botoxcosmetic.com 1-800-BOTOXMD APC02LD14 141521